Publications

For a complete listing of publications on PubMed, click here

2024

Lu D, Faizi M, Drown B, Simerzin A, François J, Bradshaw G, Kelleher N, Jambhekar A, Gunawardena J, Lahav G. “Temporal regulation of gene expression through integration of p53 dynamics and modifications.” (2024) Sci Adv. 10(43):eadp2229. Abstract

Jiménez A, Lucchetti A, Heltberg MS, Moretto L, Sanchez C, Jambhekar A, Jensen MH, Lahav G. “Entrainment and multi-stability of the p53 oscillator in human cells.” (2024) Cell Syst. 10.1016/j.cels.2024.09.001. Abstract

Faizi M, Fellers RT, Lu D, Drown BS, Jambhekar A, Lahav G, Kelleher NL, Gunawardena J. “MSModDetector: a tool for detecting mass shifts and post-translational modifications in individual ion mass spectrometry data.” (2024) Bioinformatics. 3;40(6) 10.1093/bioinformatics/btae335. Abstract

Ke S, Dang F, Wang L, Chen JY, Naik MT, Li W, Thavamani A, Kim N, Naik NM, Sui H, Tang W, Qiu C, Koikawa K, Batalini F, Stern Gatof E, Isaza DA, Patel JM, Wang X, Clohessy JG, Heng YJ, Lahav G, Liu Y, Gray NS, Zhou XZ, Wei W, Wulf GM, Lu KP. “Reciprocal antagonism of PIN1-APC/C(CDH1) governs mitotic protein stability and cell cycle entry.” (2024) Nat Commun. 15;15(1):3220. Abstract

Jambhekar A, Ackerman EE, Alpay BA, Lahav G, Lovitch SB. “Comparison of TP53 Mutations in Myelodysplasia and Acute Leukemia Suggests Divergent Roles in Initiation and Progression.” (2024) medRxiv. 2023.09.04.23295042. Abstract

2023

Polychronidou M, Hou J, Babu MM, Liberali P, Amit I, Deplancke B, Lahav G, Itzkovitz S, Mann M, Saez-Rodriguez J, Theis F, Eils R. “Single-cell biology: what does the future hold?” (2023) Mol Syst Biol. 19(7):e11799. Abstract

Chen JY, Hug C, Reyes J, Tian C, Gerosa L, Fröhlich F, Ponsioen B, Snippert HJG, Spencer SL, Jambhekar A, Sorger PK, Lahav G. “Multi-range ERK responses shape the proliferative trajectory of single cells following oncogene induction." (2023) Cell Rep. 42(3):112252. Abstract

2022

Venkatachalam V, Jambhekar A, Lahav G. “Reading oscillatory instructions: How cells achieve time-dependent responses to oscillating transcription factors”. (2022) Curr Opin Cell Biol. 77:102099. Abstract

Jiménez A, Lu Y, Jambhekar A, Lahav G. “Principles, mechanisms and functions of entrainment in biological oscillators”. (2022) Interface Focus. (3):20210088. Abstract

Jiménez A, Lu D, Kalocsay M, Berberich MJ, Balbi P, Jambhekar A, Lahav G. “Time-series transcriptomics and proteomics reveal alternative modes to decode p53 oscillations”. (2022) Mol Syst Biol. (3):e10588. Abstract

Lu D, Jambhekar A, Lahav G. (2022) “Louder for longer: Myc amplifies gene expression by extended transcriptional bursting”. Cell Reports. 38(9):110470. Abstract

2021

Oren Y, Tsabar M, Cuoco MS, Amir-Zilberstein L, Cabanos HF, Hütter JC, Hu B, Thakore PI, Tabaka M, Fulco CP, Colgan W, Cuevas BM, Hurvitz SA, Slamon DJ, Deik A, Pierce KA, Clish C, Hata AN, Zaganjor E, Lahav G, Politi K, Brugge JS, Regev A. (2021) “Cycling cancer persister cells arise from lineages with distinct programs”. Nature. 596(7873):576-582. Abstract

Nandagopal N, Jambhekar A, Lahav G. (2021) “Preparing macrophages for the future”. Science. 18;372(6548):1263-1264. Abstract

Stewart-Ornstein J, Iwamoto Y, Miller MA, Prytyskach MA, Ferretti S, Holzer P, Kallen J, Furet P, Jambhekar A, Forrester WC, Weissleder R, Lahav G. (2021) “p53 dynamics vary between tissues and are linked with radiation sensitivity”. Nat Commun. 9;12(1):898. Abstract

Tsabar M, Lovitch SB, Jambhekar A, Lahav G. (2021) “Connecting Timescales in Biology: Can Early Dynamical Measurements Predict Long-Term Outcomes?” Trends Cancer. 7(4):301-308. Abstract

2020

Tsabar M, Mock CS, Venkatachalam V, Reyes J, Karhohs KW, Oliver TG, Regev A, Jambhekar A, Lahav G. (2020) “A Switch in p53 Dynamics Marks Cells That Escape from DSB-Induced Cell Cycle Arrest”. Cell Rep. 4;32(5):107995. Abstract

Hafner A, Reyes J, Stewart-Ornstein J, Tsabar M, Jambhekar A, Lahav G. (2020) “Quantifying the Central Dogma in the p53 Pathway in Live Single Cells”. Cell Syst. 24;10(6):495-505.e4. Abstract

Granada AE, Jiménez A, Stewart-Ornstein J, Blüthgen N, Reber S, Jambhekar A, Lahav G. (2020) “The effects of proliferation status and cell cycle phase on the responses of single cells to chemotherapy”. Mol Biol Cell. 1;31(8):845-857. Abstract

Hafner A, Kublo L, Tsabar M, Lahav G, Stewart-Ornstein J. (2020) “Identification of universal and cell-type specific p53 DNA binding”. BMC Mol Cell Biol. 18;21(1):5. Abstract

Ardon-Dryer K, Mock C, Reyes J, Lahav G. (2020) “The effect of dust storm particles on single human lung cancer cells”. Environ Res. 181:108891. Abstract

2019

Heltberg ML, Chen SH, Jiménez A, Jambhekar A, Jensen MH and Lahav G. (2019) “Inferring Leading Interactions in the p53/Mdm2/Mdmx Circuit through Live-Cell Imaging and Modeling”. Cell Syst. 18;9(6):548-558.e5. Abstract

Gilad T, Reves J, Chen JY, Lahav G and Riklin Raviv T. (2019) “Fully unsupervised symmetry-based mitosis detection in time-lapse cell microscopy.” Bioinformatics, 25;15: Pp. 2644-2653. Abstract

Hafner A, Bulyk ML, Jambhekar A and Lahav G. (2019) “The multiple mechanisms that regular p53 activity and cell fate.” Nat Rev Mol Cell Bio, 20;4: Pp. 199-210. Abstract

2018

Reyes J, Chen JY, Stewart-Ornstein J, Karhohs KW, Mock CS and Lahav G. (2018) “Fluctuations in p53 Signaling Allow Escape from Cell-Cycle Arrest.” Molecular Cell, 71;4: Pp. 581-591.e5. Abstract

Arbelle A, Reyes J, Chen JY, Lahav G and Riklin Raviv T. (2018) “A probabilistic approach to joint cell tracking and segmentation in high-throughput microscopy videos.” Medical Image Analysis, 47: Pp. 140-152. Abstract

Reyes, J and Lahav, G. (2018) “Leveraging and coping with uncertainty in the response of individual cells to therapy.” Current Opinion in Biotechnology, 51: Pp. 109-115. Abstract

Chakrabarti S, Paek A, Reyes J, Lasick K, Lahav G and Michor F. (2018) “Hidden heterogeneity and circadian-controlled cell fate inferred from single cell lineages.” Nature Communications 9:, 5372. Abstract

Deepesh Agarwal, Ryan T. Fellers, Bryan P. Early, Dan Lu, Caroline J. DeHart, Philip D. Compton, Paul, M. Thomas, Galit Lahav, Neil L. Kelleher and Jeremy Gunawardena. (2018) “Analysing protein post-translational modform regions by linear programming.” bioRxiv. 2018. Abstract

Caroline J. DeHart, Luca Fornelli, Lissa C. Anderson, Ryan T. Fellers, Dan Lu, Christopher L. Hendrickson, Galit Lahav, Jeremy Gunawardena and Neil L. Kelleher. (2018) “A multi-modal proteomics strategy for characterizing posttranslational modifications of tumor suppressor p53 reveals many sites but few modified forms.” bioRxiv. Abstract

2017

Stewart-Ornstein J, Cheng HWJ and Lahav G. (2017) “Conservation and Divergence of p53 Oscillation Dynamics across Species.” Cell Systems, 5, 4, Pp. 410-417. Abstract

Hafner A, Stewart-Ornstein J, Purvis JE, Forrester WC, Bulyk ML and Lahav G. (2017) “p53 pulses lead to distinct patterns of gene expression albeit similar DNA-binding dynamics.” Nature Structural & Molecular Biology, 24, Pp. 840–847. Abstract

Oppenheim A and Lahav G. (2017) “The puzzling interplay between p53 and Sp1.” Aging (Albany, NY) 9 (5), Pp. 1355-1356. Abstract

Tsabar M and Lahav G. (2017) “The Single-Cell Yin and Yang of Live Imaging and Transcriptomics.” Cell Systems, 4, 4, Pp. 375-377. Abstract

Stewart-Ornstein J and Lahav G. (2017) “p53 dynamics in response to DNA damage vary across cell lines and are shaped by efficiency of DNA repair and activity of the kinase ATM.” Science Signaling, 10, 476. Abstract

Stewart-Ornstein J and Lahav G. (2017) “Integrating genomic information and signaling dynamics for efficient cancer therapy.” Current Opinion in Systems Biology, 1, February 2017, Pp. 38-43. Abstract

2016

Chen SH and Lahav G. (2016) “Two is better than one; toward a rational design of combinatorial therapy.” Current Opinion in Structural Biology, 41, Pp. 145-150. Abstract

Drayman N, Ben-Nun-Shaul O, Butin-Israeli V, Srivastava R, Rubinstein AM, Mock CS, Elyada E, Ben-Neriah Y, Lahav G and Oppenheim A. (2016) “p53 elevation in human cells halt SV40 infection by inhibiting T-ag expression.” Oncotarget, 7, Pp. 52643-52660. Abstract

Paek AL, Liu JC, Loewer A, Forrester WC and Lahav G. (2016) “Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing.” Cell, 165, 3, Pp. 631-642. Abstract

Chen SH, Forrester W and Lahav G. (2016) “Schedule-dependent interaction between anticancer treatments.” Science, 351, 6278, Pp. 1204-1208. Abstract

Stewart-Ornstein J and Lahav G. (2016) “Dynamics of CDKN1A in Single Cells Defined by an Endogenous Fluorescent Tagging Toolkit.” Cell Reports, 14, 7, Pp. 1800-1811. Abstract

2015

Lande-Diner L, Stewart-Ornstein J, Weitz CJ and Lahav G. (2015) “Single-cell analysis of circadian dynamics in tissue explants.” Molecular Biology of the Cell, 26, 22. Abstract

2014

Gaglia G and Lahav G. (2014) “Constant rate of p53 tetramerization in response to DNA damage controls the p53 response.” Molecular Systems Biology, 10, 10, Pp. 1-8. Abstract

Liu JC, Lerou PH and Lahav G. (2014) “Stem cells: balancing resistance and sensitivity to DNA damage.” Trends in Cell Biology, 24, 5, Pp. 268-274. Abstract

2013

Loewer A, Karanam K, Mock C and Lahav G. (2013) “The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold.” BMC Biology, 11, 114. Abstract

Liu JC, Guan X, Ryan JA, Rivera AG, Mock C, Agrawal V, Letai A, Lerou PH and Lahav G. (2013) “High mitochondrial priming sensitizes hESCs to DNA-damage-induced apoptosis.” Cell Stem Cell, 13, 4, Pp. 483-491. Abstract

Gaglia G, Guan Y, Shah JV and Lahav G. (2013) “Activation and control of p53 tetramerization in individual living cells.” Proceedings of the National Academy of Sciences of the United States of America, 110, 38, Pp. 15497-15501. Abstract

Karanam K, Loewer A and Lahav G. (2013) “Dynamics of the DNA damage response: insights from live-cell imaging.” Briefings in Functional Genomics, 12, 2, Pp. 109-117. Abstract

Kafri R, Levy J, Ginzberg MB, Oh S, Lahav G and Kirschner MW. (2013) “Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle.” Nature, 494, Pp. 480-483. Abstract

Purvis JE and Lahav G. (2013) “Encoding and decoding cellular information through signaling dynamics.” Cell, 152, 5, Pp. 945-956. Abstract

2012

Karanam K, Kafri R, Loewer A and Lahav G. (2012) “Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase.” Molecular Cell, 47, 2, Pp. 320-9. Abstract

Purvis JE, Karhohs KW, Mock C, Batchelor E, Loewer A and Lahav G. (2012) “p53 dynamics control cell fate.” Science, 336, 6087, Pp. 1440-1444. Abstract

Purvis JE and Lahav G. (2012) “Decoding the insulin signal.” Molecular Cell, 46, 6, Pp. 715-716. Abstract

Orth JD, Loewer A, Lahav G and Mitchison TJ. (2012) “Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction.” Molecular Biology of the Cell, 23, 4, Pp. 567-76. Abstract

2011

Loewer A and Lahav G. (2011) “We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells.” Current Opinion in Genetics & Development, 21, 6, Pp. 753-758. Abstract

Batchelor E, Loewer A, Mock C and Lahav G. (2011) “Stimulus-dependent dynamics of p53 in single cells.” Molecular Systems Biology, 7. Abstract

Batchelor E and Lahav G. (2011) “Suppressing variation in synthetic circuits.” Molecular Systems Biology, 7, Pp. 520. Abstract

OLDER

For older publications older than 2011, please click here.